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What is an Erythrocye and How Does it Contribute to the Immune System?

Erythrocytes, commonly known as red blood cells (RBCs), are traditionally recognized for their role in oxygen transport. However, recent studies have begun to elucidate their contributions to the immune system. This review delves into the nature of erythrocytes, their traditional functions, and their emerging roles in immune regulation and defense.

Erythrocytes are the most abundant cells in human blood. Their primary function is to transport oxygen from the lungs to tissues and return carbon dioxide for exhalation. Erythrocytes are characterized by their biconcave shape, lack of nucleus and organelles, and the presence of hemoglobin, a protein that binds oxygen (Guyton and Hall, “Textbook of Medical Physiology”, 2016).

Historically, the role of erythrocytes in the body has been understood purely in the context of respiratory gas transport. Their shape and composition optimize their efficiency in oxygen and carbon dioxide transport, making them essential for cellular respiration and energy production in tissues.

Recent research has suggested that erythrocytes play a role in immune surveillance. They can bind to and neutralize various substances in the bloodstream, including toxins, and pathogens, through specific and nonspecific interactions. This binding facilitates the removal of these substances from the bloodstream, contributing to the body’s defense (Morera and MacKenzie, “Frontiers in Immunology”, 2017).

Additionally, erythrocytes have been shown to influence the behavior of immune cells. They can modulate the activity of macrophages and dendritic cells, often enhancing their phagocytic activity. This interaction helps in the clearance of pathogens and contributes to the regulation of immune responses (Wagener et al., “Blood”, 2013).

Furthermore, erythrocytes are involved in the regulation of inflammation. They can absorb and neutralize inflammatory mediators, such as cytokines, thereby modulating the inflammatory response. This role is particularly important in preventing excessive or chronic inflammation that can lead to tissue damage (Closa and Folch-Pi, “Journal of Leukocyte Biology”, 2004).

Erythrocytes, while primarily known for their role in oxygen transport, also play a significant and emerging role in the immune system. Their contributions to immune surveillance, modulation of immune cells, and regulation of inflammation underscore a complex interplay between respiratory and immune functions. Understanding these roles not only expands our knowledge of erythrocyte functions but also opens new avenues for research in immunology and hematology.

 

References:

Guyton A.C., Hall J.E. “Textbook of Medical Physiology”, 13th Edition, Elsevier, 2016.

Morera D., MacKenzie S.A. “Erythrocytes as Modulators of the Immune Response”. Frontiers in Immunology, 2017.

Wagener F.A.D.T.G., et al. “The Heme-Hemopexin Complex Modulates the Immune Response”. Blood, 2013.

Closa D., Folch-Pi J. “Role of Erythrocytes in the Regulation of Inflammation”. Journal of Leukocyte Biology, 2004.

If you have any questions about the Berkeley Formula Diindolylmethane (DIM) Supplement & Immune System Booster, please feel free to contact our customer service department at 877-777-0719 (9AM-5PM M-F PST) and our representatives will be happy to answer any questions that you may have. We will be glad to share with you why the Berkeley Formula is the DIM supplement of choice by nutritional scientists, medical professionals and biomedical investigators worldwide.

Romanesco Broccoli with a Natural Fractal Pattern

Romanesco Broccoli

What is an Erythrocye and How Does it Contribute to the Immune System?

Erythrocytes, commonly known as red blood cells (RBCs), are traditionally recognized for their role in oxygen transport. However, recent studies have begun to elucidate their contributions to the immune system. This review delves into the nature of erythrocytes, their traditional functions, and their emerging roles in immune regulation and defense.

Erythrocytes are the most abundant cells in human blood. Their primary function is to transport oxygen from the lungs to tissues and return carbon dioxide for exhalation. Erythrocytes are characterized by their biconcave shape, lack of nucleus and organelles, and the presence of hemoglobin, a protein that binds oxygen (Guyton and Hall, “Textbook of Medical Physiology”, 2016).

Historically, the role of erythrocytes in the body has been understood purely in the context of respiratory gas transport. Their shape and composition optimize their efficiency in oxygen and carbon dioxide transport, making them essential for cellular respiration and energy production in tissues.

Recent research has suggested that erythrocytes play a role in immune surveillance. They can bind to and neutralize various substances in the bloodstream, including toxins, and pathogens, through specific and nonspecific interactions. This binding facilitates the removal of these substances from the bloodstream, contributing to the body’s defense (Morera and MacKenzie, “Frontiers in Immunology”, 2017).

Additionally, erythrocytes have been shown to influence the behavior of immune cells. They can modulate the activity of macrophages and dendritic cells, often enhancing their phagocytic activity. This interaction helps in the clearance of pathogens and contributes to the regulation of immune responses (Wagener et al., “Blood”, 2013).

Furthermore, erythrocytes are involved in the regulation of inflammation. They can absorb and neutralize inflammatory mediators, such as cytokines, thereby modulating the inflammatory response. This role is particularly important in preventing excessive or chronic inflammation that can lead to tissue damage (Closa and Folch-Pi, “Journal of Leukocyte Biology”, 2004).

Erythrocytes, while primarily known for their role in oxygen transport, also play a significant and emerging role in the immune system. Their contributions to immune surveillance, modulation of immune cells, and regulation of inflammation underscore a complex interplay between respiratory and immune functions. Understanding these roles not only expands our knowledge of erythrocyte functions but also opens new avenues for research in immunology and hematology.

 

References:

Guyton A.C., Hall J.E. “Textbook of Medical Physiology”, 13th Edition, Elsevier, 2016.

Morera D., MacKenzie S.A. “Erythrocytes as Modulators of the Immune Response”. Frontiers in Immunology, 2017.

Wagener F.A.D.T.G., et al. “The Heme-Hemopexin Complex Modulates the Immune Response”. Blood, 2013.

Closa D., Folch-Pi J. “Role of Erythrocytes in the Regulation of Inflammation”. Journal of Leukocyte Biology, 2004.

If you have any questions about the Berkeley Formula Diindolylmethane (DIM) Supplement & Immune System Booster, please feel free to contact our customer service department at 877-777-0719 (9AM-5PM M-F PST) and our representatives will be happy to answer any questions that you may have. We will be glad to share with you why the Berkeley Formula is the DIM supplement of choice by nutritional scientists, medical professionals and biomedical investigators worldwide.

Romanesco Broccoli with a Natural Fractal Pattern

Romanesco Broccoli
Berkeley Immune Support Formula Immune Booster Supplement
Alex Amini, M.D. Quote

Alex Amini, M.D.
Infectious Disease Specialist
Kaiser Permanente

Broccoli
Broccoli:
Diindolylmethane
Sulforaphane
Selenium
Spinach
Spinach:
Lutein
Zeaxanthin
Citrus Fruits
Citrus Fruits:
Citrus Bioflavonoids
Tomato
Tomato:
Lycopene
Broccoli
Broccoli:
Diindolylmethane
Sulforaphane
Selenium
  • Powerful Nutritional Immune Booster

    Bioavailable Nutrient Delivery System

  • Diindolylmethane (DIM):

    Immune, Breast, Prostate & Colon Heath

  • Sulforaphane:

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  • Selenium:

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  • Lycopene:

    Cardiovascular, Breast & Prostate Health

  • Lutein:

    Immune, Vision, Prostate & Skin Health

  • Zeaxanthin:

    Vision Health

  • Vitamin D3:

    Immune Support & Bone Health

  • Citrus Bioflavonoids:

    Immune & Cardiovascular Health

  • Zinc:

    Immune, Breast, Prostate & Vision Health

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