Product

The Berkeley Immune Support Formula is a dietary supplement with proprietary nutrient delivery technology exclusively developed by Berkeley BioSciences, Inc. It is the result of over three decades of research by some of the leading scientists in the field of nutrition and molecular biology. The supplement comes in bottles of 60 vegetarian capsules–a 30 day supply. Its unique formula contains nutritional ingredients that enhance the immune system and support multiple organ systems throughout the body: breast, prostate, cardiovascular, vision, skin and colon health.

Epidemiology

Epidemiological studies have confirmed that people who regularly consume Brassica vegetables (broccoli, cauliflower, cabbage, kale, brussel sprouts) enjoy significant health benefits.1,2 Scientists have often attributed this “Brassica Effect” to the existence of three key health promoting nutrients found in these vegetables: Diindolylmethane, Sulforaphane and Selenium.3

The Berkeley Immune Support Formula provides enhanced absorption bioavailable formulations of all three of these important health promoting nutrients found in Brassica vegetables. Berkeley DIM Immune Complex™ is significantly more bioavailable than standard DIM supplements on the market. It has been scientifically formulated to account for the specific molecular biology and lipophilic nature of Diindolylmethane. 

Berkeley Broccoli Sprout™ delivers Myrosinated Sulforaphane, the first formulation on the market that increases the bioavailability of Sulforaphane as it aids in the cleavage of the active compound from its precursor glucosinolate complex.

Methylselenocysteine is the natural form of Selenium found in broccoli and garlic that is more bioavailable and biologically active than synthetic Seleniums used in most multi-vitamins. The Selenium and Sulforphane in the Berkeley Formula are specifically formulated to increase their synergistic biological activity as has been established in scientific literature.

Additionally, the Berkeley Formula provides Berkeley Lycopene™ (enhanced absorption formulation of the key antioxidant found in tomatoes) and Berkeley Lutein™ & Berkeley Zeaxanthin™ (enhanced absorption formulations of two important phytonutrients found in spinach). 

The formula also includes Berkeley Citrus Bioflavonoids™ providing premium bioflavonoids extracted from citrus fruits and citrus peels along with Vitamin D3 for additional immune support and bone health. The Vitamin D3 (cholecalciferol) in the Berkeley Immune Support Formula is the most bioavailable and efficacious form of Vitamin D in the market, significantly more bioavailable than the Vitamin D2 (ergocalciferol) found in most multivitamins.

The zinc in the formula provides additional support for immune function and promotes breast, prostate and vision health. The result is a premium nutritional supplement that boosts your immune system and supports the health of your whole body. For best results, we suggest that you take the Berkeley Immune Support Formula with your daily multi-vitamin and make it a part of your long-term nutritional wellness program.

The Vitamin D, Selenium and Zinc in the Berkeley Immune Support Formula, when taken with a standard multi-vitamin, are well within the safety limits established by the United States Institute of Medicine. The Berkeley Immune Support Formula is designed to complement and enhance a multi-vitamin regimen, if one is in place. It is also a very effective supplement if taken alone. The upper limit set for Vitamin D is 4000 IU (100 mcg), 400 mcg for Selenium and 40mg for Zinc.

Product Label

To view the product label, please click here.

To view the product label

 please click here.

Supplement Information

Berkeley DIM Immune Complex™ is a Proprietary Bioavailable Diindolylmethane Complex consisting of: Diindolylmethane (37.5%), Brown Rice, Cellulose, Lecithin (Sunflower), Medium Chain Triglycerides, and Olive Oil. Berkeley Lutein™, Berkeley Lycopene™, Berkeley Zeaxanthin™ and Berkeley Broccoli Sprout™ are proprietary enhanced absorption formulations of lutein, lycopene, zeaxanthin, and sulforaphane. Other ingredients: Hypromellose, Rice Fiber, White Rice, Ascorbyl Palmitate, Dicalcium Phosphate.

This formula has no artificial colors and no dairy products.

Suggested Use: Take one capsule twice daily with food or as directed by your healthcare professional.

Note: You should not use this product if you are pregnant or lactating. Persons taking prescription medications or indifividuals with chronic health conditions should consult with a healthcare professional before taking this product. A harmless change in urine color may occur during usage. Keep bottle out of reach of children. Store in a cool dry place.

Manufacturing

Only the highest quality ingredients are used for the manufacturing of the Berkeley Immune Support Formula. Our manufacturing plant is a GMP-certified facility in the United States approved for pharmaceutical-grade production and as such our product manufacturing standards exceed the general standards set for the manufacturing of nutritional supplements.

Broccoli Powder and Extract Products

The Berekely Formula provides a nutritional solution far greater than broccoli powder and extract pills currently sold in the market. Most broccoli powder and extract pills in the market do not provide DIM or Sulforaphane as their manufacturing process does not allow the formation of these nutrients. These pills also do not provide Lycopene, Lutein, Zeaxanthin, Selenium, Zinc and the Vitamin D provided by the Berkeley Immune Support Formula.

Key Product Differentiators

The Original Discoverers of DIM at Berkeley are the Co-Founders of our Company

Our team has published more scientific papers on Diindolylmethane than any other scientific team in the world. We take pride in that and we use our knowledge, experience and expertise in working with this molecule for over 30 years to bring a product that we believe is superior to others in helping people lead healthier lives.

Our product was formulated by doctors for doctors, biomedical investigators and discerning consumers who want the very best from an immune enhancing nutritional product. Many of our clients are physicians who resell our formula through their clinical practice–oncologists, immunologists, infectious disease specialists and general practitioners world-wide who have been following our research for years.

World’s First Cyclic-Trimer Filtered Diindolylmethane Supplement

The Berkeley Formula is the world’s first cyclic-trimer filtered diindolylmethane supplement. Cyclic-Trimer is a molecule that is formed during the formation of DIM from its precursor compound Indole-3-Carbinol. It is formed along with DIM when I3C goes through an acid catalysis reaction to form both DIM and Ctr (Cyclic-Trimer). The formal scientific name for this compound is: 5,6,11,12,17,18-hexahydrocyclonona[1,2-b:4,5-b‘:7,8-b‘ ‘]triindole. It is otherwise known as “I3C-CTr” or simply “Ctr”.

As we were the first scientific team to discover the undesirable biological activities associated with Ctr, we have developed proprietary filtration systems in collaboration with our manufacturing partners to remove Ctr formed within the DIM that is manufactured and used within our formulation. No other dietary supplement company in the world that we know of goes through such costs and extent to assure a safe, pure and efficacious product.

The Cyclic-Trimer I3C Molecule (Ctr), as we discovered and published at Berkeley while we were studying the formation of DIM from I3C, acts like a hormone within the body, whereas DIM at clinically efficacious dosages (such as what we provide in our formula) does not. Ctr biologically acts like estrogen. We therefore believe that it is important that it be filtered out and removed from the DIM that people consume as a dietary supplement.

While most supplement vendors on the internet are focused on profits and keeping their costs down, our focus is on quality, clinical efficacy and scientific integrity. In all of the preclinical studies we have published at Berkeley on DIM that are the underpinnings of why DIM has become such a popular dietary supplement worldwide, we have only used purified DIM, wherein the Ctr had been filtered out. We believe consumers of DIM dietary supplements should be entitled to the same high-grade and highly purified DIM as those that we have used in our studies at Berkeley—scientific grade DIM, not just nutraceutical grade DIM.

Our production costs are therefore significantly higher compared to other DIM vendors on the internet, but so is the quality and purity of the final product that we sell to our customers, many of whom are doctors and biomedical investigators like ourselves.

The scientific paper that we published at Berkeley on this matter is this one:

Chemico-Biological Interactions 2005 Apr 15;152(2-3):119-29. Xue L, Schaldach CM, Janosik T, Bergman J, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA.

No Tocophersolan Used Within Our Formulation

Tocophersolan is a synthetic vitamin E used by some DIM supplement vendors to enhance the bioavailability of DIM, however, this compound interferes with some of the key and important biological activities of DIM. As such, we don’t use it in our formulation.

No High Dose Mixed Tocopherols Used Within Our Formulation

High dose mixed tocopherols (Vitamin E mixtures) are used by some DIM supplement vendors to enhance the bioavailability of DIM, however, this high dose mixture of Vitamin E interferes with some of the key and important biological activities of DIM rendering it less effective as a dietary supplement. As such, we don’t use such a technique in our formulation.

No Bioperine or Black Pepper Extract Used Within Our Formulation

Bioperine or black pepper extract is used by some DIM supplement vendors to enhance the bioavailability of DIM, however, the safety and efficacy of this mixture has never been demonstrated in neither pre-clinical animal studies nor human clinical trials. Bioperine enhances the bioavailability of certain nutrients by reducing the natural defense systems of our GI tract making the GI tract as a whole more permeable to practically everything we put in our mouth. In so doing, it also enhances the bioavailability of trace toxins found within our foods. Preservatives, artificial colors and flavors as well as trace toxins such as heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) that are found in cooked meats are also absorbed more effectively when consumers take bioperine as a component of their dietary supplement. The pharmacokinetics of pharmeceuticals can also be altered by bioperine from dietary supplements rendering the use of the pharmaceuticals possibly unsafe for patients who regularly consume high dose bioperine products within their dietary supplements. We therefore do not use this method in our formulation.

No Artificial Colors, Flavors, or Preservatives Used Within Our Formulation

This is our philosophy. Afterall, we and our family members consume this product too.

GMP-certified Manufacturing Within the United States

Our product is manufactured within the USA in accordance with US GMP standards. Most DIM supplements sold within US online retail stores are not manufactured in the US in accordance with US GMP safety standards.

Highest Concentration of Bioavailable DIM in the Market

The Berkeley Formula provides the highest concentration of bioavailable DIM in the market today within the Berkeley DIM Immune Complex. There are no other products that we know of in the market that provide the concentration of DIM at the bioavailability that we provide to consumers within this formulation.

Money-Back Guarantee

Our product is backed by our unconditional money-back guarantee. If you or your doctor are not impressed by the effectiveness of this product, you can return it for a refund. For more information about our return policy, please visit our Customer Service page. 

Berkeley Formula Nutrikinetics

Our product goes beyond just providing DIM and other nutrients in a bioavailable manner. Our goal in the development of this product has been to pay meticulous attention to the nutrikinetics of the nutrients that we provide together. The C-maxes of each of the nutrients has been designed to overlap with each other to maximize their combined effect on the immune system and other organ systems in the body. C-max in the field of nutrition refers to the maximum concentration of a particular nutrient within the bloodstream. When two or more nutrients are noted to work well together to achieve a desired biological effect, the overlapping of their C-max curves helps to deliver maximum efficacy to end consumers. The dosages, the bioavailabilities and the kinetics of absorption of each nutrient has been engineered to achieve this maximum combined impact within the Berkeley Formula. We’re one of the few dietary supplements in the industry that has been engineered by senior nutritional scientists and molecular biologists with clinical efficacy being our number one priority.

Case Studies of Ineffective DIM Supplements Sold Online

This section is dedicated to a review of case studies of ineffective DIM supplements currently being sold to the public through countless internet websites. By reviewing these case studies, you will get a better appreciation for why the Berkeley Formula was launched by the original discoverers of DIM at Berkeley. We noticed that our scientific papers were being referenced and quoted by these supplement vendors and yet they were selling entirely ineffective products to the public. So we decided to take a stand and bring a high quality DIM supplement to market that we know delivers clinical efficacy.

Case Study #1:

Products with nutrition labels that state that their capsules or tablets contain 100-300mg of DIM per serving with no lipophilic ingredients within the formulation. When you begin to read the fine print of their label, you’ll notice that other than DIM they usually contain some rice starch and cellulose (which helps with the flow of powders in encapsulation machines). There are no lipophilic emulsifiers, excipients or surfactants included within the formulation. These formulations are the cheapest formulations of DIM being sold on the internet. They are the cheapest because they are the easiest to manufacture with the lowest cost of manufacturing and lowest cost of raw materials used. DIM, however, is a lipophilic compound. If crystalline DIM is administered without the presence of lipophilic excipients, emulsifiers and surfactants, it does not get absorbed by the GI tract very well. It generally clumps together and comes straight down the GI tract with minimal absorption.

These products are generally very ineffective with very poor bioavailabilities.

The vast majority of these DIM vendors on the internet are currently citing our scientific papers published at Berkeley on DIM to help sell their ineffective products to the public.

Case Study #2:

The product lists DIM on its label and it also lists “Bioperine” or “concentrated pepper extract” on the label with claims made by the vendors that the presence of Bioperine will improve the absorption of DIM.

The reality is that the safety and efficacy of this mixture has never been demonstrated in neither pre-clinical animal studies nor human clinical trials. There are no published scientific papers anywhere indicating that mixing Bioperine with DIM improves the bioavailability of DIM in any way.

Bioperine, generally speaking, does enhance the bioavailability of certain nutrients by reducing the natural defense systems of our GI tract making the GI tract as a whole more permeable to practically everything we put in our mouth. When DIM is not co-administered with lipophilic excipients, emulsifiers and surfactants, however, the presence of Bioperine will likely make a very small and relatively insignificant difference in the absorption of DIM. Nevertheless, this practice is not a safe way to improve the bioavailability of dietary supplements in our opinion as nutritional scientists and biomedical investigators. The reason is that this method also enhances the bioavailability of trace toxins found within our foods. Preservatives, artificial colors and flavors as well as trace amounts of highly carcinogenic toxins such as heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) that are found in cooked meats and processed foods are also absorbed more effectively when consumers take bioperine as a component of their dietary supplement. The pharmacokinetics of pharmeceuticals can also be altered by bioperine from dietary supplements rendering the use of the pharmaceuticals possibly unsafe for patients who regularly consume high dose bioperine products within their dietary supplements or consume multiple supplements per day each of which has some bioperine in it. We therefore do not use this method in our formulation and do not recommend that consumers take products that use such methods to address the bioavailability of nutrients.

Case Study #3

This third class of products sold online, do use lipophilic emulsifiers, excipients and surfactants to formulate the DIM and that’s encouraging to see, however, they use the wrong ones and do so at dosages that interfere with the basic biological activities of DIM. In this class of products you usually see “Tocophersolan” (which is a synthetic vitamin E) on the labels, or “mixed tocopherols” or “d-alpha-tocopheryl succinate”. They usually list them as part of a “complex” that contains DIM in it and they normally do not list how much synthetic or natural Vitamin E they are using to enhance the bioavailability of DIM.

Now while Vitamin E as a lipophilic nutrient can enhance the bioavailability of DIM, when it is administered in mega doses (and our research has shown that that is precisely what these vendors are doing) it actually significantly interferes with some of the key biological activities of DIM.

So while in small doses, Vitamin E may be helpful for the absorption of DIM, at very large doses, it will interfere with the activities of DIM and that is something these hyper-marketers with no scientific knowledge of the molecular biology of Diindolylmethane do not understand.

This practice renders the DIM very ineffective as a supplement and because these vendors don’t list how much Vitamin E they are using as an emulsifier, it is difficult for consumers to discern whether or not they are consuming a quality product.

Some of these vendors have even managed to push their products to be used in human clinical trials that for the most part have failed to show efficacy.

People have often reached out to us and asked us why clinical trials with such formulations have failed to show meaningful efficacy when in all of our studies that we conducted at Berkeley we were able to demonstrate significant efficacy?

Our answer has been consistent throughout the years: because the clinical trial coordinators used the wrong formulation of DIM within their study.

Case Study #4

This fourth class of DIM vendors online use “complexes” as a means to hide how much DIM is actually in the product leaving consumers confused about what it is they are getting in their formulation and how much DIM is actually in it. These vendors generally do not list what percentage of their “complex” is made up of diindolylmethane on their supplement facts sheet and consumers have to dig into the fine print on their label or packaging for this information or call their customer service department for this information. 

One example is a product that prominently cites our published studies at Berkeley and makes “Healthy Estrogen Metabolism” claims on its website and product bottles. The product gives the false impression to consumers that it is very affordable. It is generally priced at $15-25 per bottle online—the sweet spot when it comes to pricing that gives American consumers the impression that they’re getting a good value for their money.

However, consumers need to get in the habit of reading the label very carefully. When one looks closely at the label, this apparently “well-priced” product states that each of their capsules contains 100mg of a “DIM complex” and 100mg of dry broccoli and Brassica vegetable powder in it. When one reads the fine print on their label more closely, however, one notices that only 25% of their “complex” consists of DIM. The rest are just filler ingredients.

So that means that this product only provides 25mg of DIM and 100mg of broccoli powder per pill that they claim is their “daily dosage”.

As scientists who have studied DIM for over 30 years we can assure you that 25mg of DIM and 100mg of broccoli powder impart absolutely zero biological activity in human adults. This dosage is less than the threshold of biological activity within adults by a factor of 10. This product does absolutely NOTHING from a nutritional and clinical point of view. Nothing at all. If the vendors were selling air capsules with nothing in the capsules, they would be providing just as much “nutrition” as they are with this product.

So what consumers get with products like this is very nice packaging, lots of pretty pictures with people smiling, a price that implies great value, but at the end of the day, zero clinical nutrition and their hard-earned money taken by hyper-marketers under the guise of “value”.

If one were to try to get the same amount DIM that you get from the Berkeley Formula from this formulation and hundreds of others like it, one would have to spend over $150 a month on this product and consume 6-12 bottles of this product per month depending on the capsule count of the bottle that the consumer may be taking. Sometimes this product, and others like it, come in bottles of 60 capsules and sometimes 120 capsules. The quantity of capsules in their bottle is irrelevant however and frankly a component of their hyper-marketing strategy. What is relevant from the perspective of nutritional science is that this product is entirely ineffective and has absolutely no biological or clinical relevance for consumers.

Do you now see how the Berkeley Formula is a very competitively priced product?

When you’re comparing nutritional products, you need to take a very close look at the quantity of nutrients that they provide, whether or not such quantity actually imparts beneficial biological activity within the body, whether or not the nutrient is formulated in a bioavailable manner and lastly whether or not the nutrient is co-delivered with other nutrients that enhance and add to its beneficial biological activity.

Unfortunately, discerning all of this requires advanced knowledge within the field of nutritional science, knowledge that average consumers do not have, and that is exactly why we see a plethora of supplement vendors online quoting our scientific papers at Berkeley to sell entirely ineffective DIM products to the public.

At this point having done the research that we have in this market, we can say with confidence that the vast majority of the DIM supplements that consumers come across on the Internet are entirely ineffective and they fall into one or more of the categories of case studies that we have discussed above. The DIM in such formulations is either not bioavailable or it’s not bioactive or if it is bioavailable with a meaningful quantity of DIM, the wrong excipients are being used for the delivery of the DIM that interfere with its biological activities or the wrong bioavailability technology is being employed with an inferior safety profile to what one finds in the Berkeley Formula.

This is why discerning consumers who consult with expert nutritional scientists prior to purchasing DIM supplements often turn to our product for a clinically efficacious DIM supplement.

This is also why a large number of the individuals who are members within our Monthly and Quarterly Program worldwide are doctors, nutritional scientists and biomedical investigators like ourselves.

Case Study #5

This product cites our work at Berkeley and makes all kinds of claims about how “scientists have shown that DIM promotes healthy estrogen metabolism” referring to our study that we did in Marin County, California, however, when you look at the label carefully, the label states that it has “900 mcg” of Diindolylmethane in it.

What the hyper-marketers in this case are doing is they are betting that the average American consumer does not know the difference between micrograms and milligrams and by listing a large number before the measurement type, they are betting that people will be more impressed by the number than what the number actually means.

Micrograms and milligrams are part of the metric measurement system that most Americans are not familiar with and this is how this company is exploiting people’s lack of knowledge.

Eash single milligram (mg) contains 1000 micrograms (mcg).

So a product containing 900 mcg of DIM in each capsule has less than 1 mg of DIM in it, because that amount equates to just 0.9 mg of DIM. 0.9 mg of DIM is not a biologically active quantity of DIM. This quantity of DIM achieves nothing. It has no nutritional value at all for anyone consuming it. Consumers would have to consume hundreds of these capsules in order to get the same quantity of DIM that they would get in just two of our capsules.

We hope that you have found these case studies to be informative and educational. 

Notes

1. Prospective Study of Fruit and Vegetable Intake and Risk of Prostate Cancer. Journal of the National Cancer Institute. 2007 Jul 24; Krish VA, Peters U, Mayne ST, Subar AF, Chatterjee N, Johnson CC, Hayes RB. Click here to view reference at the US National Library of Medicine.

2. Greater vegetable and fruit intake is associated with a lower risk of breast cancer among Chinese women. International Journal of Cancer. 2009 Jul 1;125(1):181-8. Zhang CX, Ho SC, Chen YM, Fu JH, Check SZ, Lin FY. Click here to view reference at the US National Library of Medicine.

3. Please visit our extensive references section at the end of our Science Page listing scientific articles on Diindolylmethane, Sulforaphane and Selenium.

Broccoli Bloom at the UC Berkeley Botanical Garden

Berkeley Botanical Garden

Product

The Berkeley Immune Support Formula is a dietary supplement with proprietary nutrient delivery technology exclusively developed by Berkeley BioSciences, Inc. It is the result of over three decades of research by some of the leading scientists in the field of nutrition and molecular biology. The supplement comes in bottles of 60 vegetarian capsules–a 30 day supply. Its unique formula contains nutritional ingredients that enhance the immune system and support multiple organ systems throughout the body: breast, prostate, cardiovascular, vision, skin and colon health.

Epidemiology

Epidemiological studies have confirmed that people who regularly consume Brassica vegetables (broccoli, cauliflower, cabbage, kale, brussel sprouts) enjoy significant health benefits.1,2 Scientists have often attributed this “Brassica Effect” to the existence of three key health promoting nutrients found in these vegetables: Diindolylmethane, Sulforaphane and Selenium.3

The Berkeley Immune Support Formula provides enhanced absorption bioavailable formulations of all three of these important health promoting nutrients found in Brassica vegetables. Berkeley DIM Immune Complex™ is significantly more bioavailable than standard DIM supplements on the market. It has been scientifically formulated to account for the specific molecular biology and lipophilic nature of Diindolylmethane.

Berkeley Broccoli Sprout™ delivers Myrosinated Sulforaphane, the first formulation on the market that increases the bioavailability of Sulforaphane as it aids in the cleavage of the active compound from its precursor glucosinolate complex. 

Methylselenocysteine is the natural form of Selenium found in broccoli and garlic that is more bioavailable and biologically active than synthetic Seleniums used in most multi-vitamins. The Selenium and Sulforphane in the Berkeley Formula are specifically formulated to increase their synergistic biological activity as has been established in scientific literature.

Additionally, the Berkeley Formula provides Berkeley Lycopene™ (enhanced absorption formulation of the key antioxidant found in tomatoes) and Berkeley Lutein™ & Berkeley Zeaxanthin™ (enhanced absorption formulations of two important phytonutrients found in spinach).

The formula also includes Berkeley Citrus Bioflavonoids™ providing premium bioflavonoids extracted from citrus fruits and citrus peels along with Vitamin D3 for additional immune support and bone health. The Vitamin D3 (cholecalciferol) in the Berkeley Immune Support Formula is the most bioavailable and efficacious form of Vitamin D in the market, significantly more bioavailable than the Vitamin D2 (ergocalciferol) found in most multivitamins. 

The zinc in the formula provides additional support for immune function and promotes breast, prostate and vision health. The result is a premium nutritional supplement that boosts your immune system and supports the health of your whole body. For best results, we suggest that you take the Berkeley Immune Support Formula with your daily multi-vitamin and make it a part of your long-term nutritional wellness program.

The Vitamin D, Selenium and Zinc in the Berkeley Immune Support Formula, when taken with a standard multi-vitamin, are well within the safety limits established by the United States Institute of Medicine. The Berkeley Immune Support Formula is designed to complement and enhance a multi-vitamin regimen, if one is in place. It is also a very effective supplement if taken alone. The upper limit set for Vitamin D is 4000 IU (100 mcg), 400 mcg for Selenium and 40mg for Zinc.

Product Label

To view the product label, please click here.

To view the product label

 please click here.

Supplement Information

Berkeley DIM Immune Complex™ is a Proprietary Bioavailable Diindolylmethane Complex consisting of: Diindolylmethane (37.5%), Brown Rice, Cellulose, Lecithin (Sunflower), Medium Chain Triglycerides, and Olive Oil. Berkeley Lutein™, Berkeley Lycopene™, Berkeley Zeaxanthin™ and Berkeley Broccoli Sprout™ are proprietary enhanced absorption formulations of lutein, lycopene, zeaxanthin, and sulforaphane. Other ingredients: Hypromellose, Rice Fiber, White Rice, Ascorbyl Palmitate, Dicalcium Phosphate.

This formula has no artificial colors and no dairy products.

Suggested Use: Take one capsule twice daily with food or as directed by your healthcare professional.

Note: You should not use this product if you are pregnant or lactating. Persons taking prescription medications or indifividuals with chronic health conditions should consult with a healthcare professional before taking this product. A harmless change in urine color may occur during usage. Keep bottle out of reach of children. Store in a cool dry place.

Manufacturing

Only the highest quality ingredients are used for the manufacturing of the Berkeley Immune Support Formula. Our manufacturing plant is a GMP-certified facility in the United States approved for pharmaceutical-grade production and as such our product manufacturing standards exceed the general standards set for the manufacturing of nutritional supplements.

Broccoli Powder and Extract Products

The Berekely Formula provides a nutritional solution far greater than broccoli powder and extract pills currently sold in the market. Most broccoli powder and extract pills in the market do not provide DIM or Sulforaphane as their manufacturing process does not allow the formation of these nutrients. These pills also do not provide Lycopene, Lutein, Zeaxanthin, Selenium, Zinc and the Vitamin D provided by the Berkeley Immune Support Formula.

Key Product Differentiators

The Original Discoverers of DIM at Berkeley are the Co-Founders of our Company

Our team has published more scientific papers on Diindolylmethane than any other scientific team in the world. We take pride in using our knowledge, experience and expertise in working with this molecule to bring a product to market that helps people lead healthier lives.

Our product was formulated by doctors for doctors, biomedical investigators and discerning consumers who want the best clinical nutrition possible from an immune enhancing product. A significant portion of our clients are physicians who resell our formula through their clinical practice–oncologists, immunologists, infectious disease specialists and general practitioners world-wide who have been following our research for years.

World’s First Cyclic-Trimer Filtered Diindolylmethane Supplement

The Berkeley Formula is the world’s first cyclic-trimer filtered diindolylmethane supplement. Cyclic-Trimer is a molecule that is formed during the formation of DIM from its precursor compound Indole-3-Carbinol. It is formed along with DIM when I3C goes through an acid catalysis reaction to form both DIM and Ctr (Cyclic-Trimer). The formal scientific name for this compound is: 5,6,11,12,17,18-hexahydrocyclonona[1,2-b:4,5-b‘:7,8-b‘ ‘]triindole. It is otherwise known as “I3C-CTr” or simply “Ctr”.

As we were the first scientific team to discover the undesirable biological activities associated with Ctr, we have developed proprietary filtration systems in collaboration with our manufacturing partners to remove Ctr formed within the DIM that is manufactured and used within our formulation. No other dietary supplement company in the world that we know of goes through such costs and extent to assure a safe, pure and efficacious product.

The Cyclic-Trimer I3C Molecule (Ctr), as we discovered and published at Berkeley while we were studying the formation of DIM from I3C, acts like a hormone within the body, whereas DIM at clinically efficacious dosages (such as what we provide in our formula) does not. Ctr biologically acts like estrogen. We therefore believe that it is important that it be filtered out and removed from the DIM that people consume as a dietary supplement.

While most supplement vendors on the internet are focused on profits and keeping their costs down, our focus is on quality, clinical efficacy and scientific integrity. In all of the preclinical studies we have published at Berkeley on DIM that are the underpinnings of why DIM has become such a popular dietary supplement worldwide, we have only used purified DIM, wherein the Ctr had been filtered out. We believe consumers of DIM dietary supplements should be entitled to the same high-grade and highly purified DIM as those that we have used in our studies at Berkeley—scientific grade DIM, not just nutraceutical grade DIM.

Our production costs are therefore significantly higher compared to other DIM vendors on the internet, but so is the quality and purity of the final product that we sell to our customers, many of whom are doctors and biomedical investigators like ourselves.

The scientific paper that we published at Berkeley on this matter is this one:

Chemico-Biological Interactions 2005 Apr 15;152(2-3):119-29. Xue L, Schaldach CM, Janosik T, Bergman J, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA.

No Tocophersolan Used Within Our Formulation

Tocophersolan is a synthetic vitamin E used by some DIM supplement vendors to enhance the bioavailability of DIM, however, this compound interferes with some of the key and important biological activities of DIM. As such, we don’t use it in our formulation.

No High Dose Mixed Tocopherols Used Within Our Formulation

High dose mixed tocopherols (Vitamin E mixtures) are used by some DIM supplement vendors to enhance the bioavailability of DIM, however, this high dose mixture of Vitamin E interferes with some of the key and important biological activities of DIM rendering it less effective as a dietary supplement. As such, we don’t use such a technique in our formulation.

No Bioperine or Black Pepper Extract Used Within Our Formulation

Bioperine or black pepper extract is used by some DIM supplement vendors to enhance the bioavailability of DIM, however, the safety and efficacy of this mixture has never been demonstrated in neither pre-clinical animal studies nor human clinical trials. Bioperine enhances the bioavailability of certain nutrients by reducing the natural defense systems of our GI tract making the GI tract as a whole more permeable to practically everything we put in our mouth. In so doing, it also enhances the bioavailability of trace toxins found within our foods. Preservatives, artificial colors and flavors as well as trace toxins such as heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) that are found in cooked meats are also absorbed more effectively when consumers take bioperine as a component of their dietary supplement. The pharmacokinetics of pharmeceuticals can also be altered by bioperine from dietary supplements rendering the use of the pharmaceuticals possibly unsafe for patients who regularly consume high dose bioperine products within their dietary supplements. We therefore do not use this method in our formulation.

No Artificial Colors, Flavors, or Preservatives Used Within Our Formulation

This is our philosophy. Afterall, we and our family members consume this product too.

GMP-certified Manufacturing Within the United States

Our product is manufactured within the USA in accordance with US GMP standards. Most DIM supplements sold within US online retail stores are not manufactured in the US in accordance with US GMP safety standards.

Highest Concentration of Bioavailable DIM in the Market

The Berkeley Formula provides the highest concentration of bioavailable DIM in the market today within the Berkeley DIM Immune Complex. There are no other products that we know of in the market that provide the concentration of DIM at the bioavailability that we provide to consumers within this formulation.

Money-Back Guarantee

Our product is backed by our unconditional money-back guarantee. If you or your doctor are not impressed by the effectiveness of this product, you can return it for a refund. For more information about our return policy, please visit our Customer Service page. 

Berkeley Formula Nutrikinetics

Our product goes beyond just providing DIM and other nutrients in a bioavailable manner. Our goal in the development of this product has been to pay meticulous attention to the nutrikinetics of the nutrients that we provide together. The C-maxes of each of the nutrients has been designed to overlap with each other to maximize their combined effect on the immune system and other organ systems in the body. C-max in the field of nutrition refers to the maximum concentration of a particular nutrient within the bloodstream. When two or more nutrients are noted to work well together to achieve a desired biological effect, the overlapping of their C-max curves helps to deliver maximum efficacy to end consumers. The dosages, the bioavailabilities and the kinetics of absorption of each nutrient has been engineered to achieve this maximum combined impact within the Berkeley Formula. We’re one of the few dietary supplements in the industry that has been engineered by senior nutritional scientists and molecular biologists with clinical efficacy being our number one priority.

Case Studies of Ineffective DIM Supplements Sold Online

This section is dedicated to a review of case studies of ineffective DIM supplements currently being sold to the public through countless internet websites. By reviewing these case studies, you will get a better appreciation for why the Berkeley Formula was launched by the original discoverers of DIM at Berkeley. We noticed that our scientific papers were being referenced and quoted by these supplement vendors and yet they were selling entirely ineffective products to the public. So we decided to take a stand and bring a high quality DIM supplement to market that we know delivers clinical efficacy.

Case Study #1:

Products with nutrition labels that state that their capsules or tablets contain 100-300mg of DIM per serving with no lipophilic ingredients within the formulation. When you begin to read the fine print of their label, you’ll notice that other than DIM they usually contain some rice starch and cellulose (which helps with the flow of powders in encapsulation machines). There are no lipophilic emulsifiers, excipients or surfactants included within the formulation. These formulations are the cheapest formulations of DIM being sold on the internet. They are the cheapest because they are the easiest to manufacture with the lowest cost of manufacturing and lowest cost of raw materials used. DIM, however, is a lipophilic compound. If crystalline DIM is administered without the presence of lipophilic excipients, emulsifiers and surfactants, it does not get absorbed by the GI tract very well. It generally clumps together and comes straight down the GI tract with minimal absorption.

These products are generally very ineffective with very poor bioavailabilities. 

The vast majority of these DIM vendors on the internet are currently citing our scientific papers published at Berkeley on DIM to help sell their ineffective products to the public.

Case Study #2:

The product lists DIM on its label and it also lists “Bioperine” or “concentrated pepper extract” on the label with claims made by the vendors that the presence of Bioperine will improve the absorption of DIM.

The reality is that the safety and efficacy of this mixture has never been demonstrated in neither pre-clinical animal studies nor human clinical trials. There are no published scientific papers anywhere indicating that mixing Bioperine with DIM improves the bioavailability of DIM in any way.

Bioperine, generally speaking, does enhance the bioavailability of certain nutrients by reducing the natural defense systems of our GI tract making the GI tract as a whole more permeable to practically everything we put in our mouth. When DIM is not co-administered with lipophilic excipients, emulsifiers and surfactants, however, the presence of Bioperine will likely make a very small and relatively insignificant difference in the absorption of DIM. Nevertheless, this practice is not a safe way to improve the bioavailability of dietary supplements in our opinion as nutritional scientists and biomedical investigators. The reason is that this method also enhances the bioavailability of trace toxins found within our foods. Preservatives, artificial colors and flavors as well as trace amounts of highly carcinogenic toxins such as heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) that are found in cooked meats and processed foods are also absorbed more effectively when consumers take bioperine as a component of their dietary supplement. The pharmacokinetics of pharmeceuticals can also be altered by bioperine from dietary supplements rendering the use of the pharmaceuticals possibly unsafe for patients who regularly consume high dose bioperine products within their dietary supplements or consume multiple supplements per day each of which has some bioperine in it. We therefore do not use this method in our formulation and do not recommend that consumers take products that use such methods to address the bioavailability of nutrients.

Case Study #3

This third class of products sold online, do use lipophilic emulsifiers, excipients and surfactants to formulate the DIM and that’s encouraging to see, however, they use the wrong ones and do so at dosages that interfere with the basic biological activities of DIM. In this class of products you usually see “Tocophersolan” (which is a synthetic vitamin E) on the labels, or “mixed tocopherols” or “d-alpha-tocopheryl succinate”. They usually list them as part of a “complex” that contains DIM in it and they normally do not list how much synthetic or natural Vitamin E they are using to enhance the bioavailability of DIM.

Now while Vitamin E as a lipophilic nutrient can enhance the bioavailability of DIM, when it is administered in mega doses (and our research has shown that that is precisely what these vendors are doing) it actually significantly interferes with some of the key biological activities of DIM.

So while in small doses, Vitamin E may be helpful for the absorption of DIM, at very large doses, it will interfere with the activities of DIM and that is something these hyper-marketers with no scientific knowledge of the molecular biology of Diindolylmethane do not understand.

This practice renders the DIM very ineffective as a supplement and because these vendors don’t list how much Vitamin E they are using as an emulsifier, it is difficult for consumers to discern whether or not they are consuming a quality product.

Some of these vendors have even managed to push their products to be used in human clinical trials that for the most part have failed to show efficacy.

People have often reached out to us and asked us why clinical trials with such formulations have failed to show meaningful efficacy when in all of our studies that we conducted at Berkeley we were able to demonstrate significant efficacy?

Our answer has been consistent throughout the years: because the clinical trial coordinators used the wrong formulation of DIM within their study.

Case Study #4

This fourth class of DIM vendors online use “complexes” as a means to hide how much DIM is actually in the product leaving consumers confused about what it is they are getting in their formulation and how much DIM is actually in it. These vendors generally do not list what percentage of their “complex” is made up of diindolylmethane on their supplement facts sheet and consumers have to dig into the fine print on their label or packaging for this information or call their customer service department for this information. 

One example is a product that prominently cites our published studies at Berkeley and makes “Healthy Estrogen Metabolism” claims on its website and product bottles. The product gives the false impression to consumers that it is very affordable. It is generally priced at $15-25 per bottle online—the sweet spot when it comes to pricing that gives American consumers the impression that they’re getting a good value for their money.

However, consumers need to get in the habit of reading the label very carefully. When one looks closely at the label, this apparently “well-priced” product states that each of their capsules contains 100mg of a “DIM complex” and 100mg of dry broccoli and Brassica vegetable powder in it. When one reads the fine print on their label more closely, however, one notices that only 25% of their “complex” consists of DIM. The rest are just filler ingredients.

So that means that this product only provides 25mg of DIM and 100mg of broccoli powder per pill that they claim is their “daily dosage”.

As scientists who have studied DIM for over 30 years we can assure you that 25mg of DIM and 100mg of broccoli powder impart absolutely zero biological activity in human adults. This dosage is less than the threshold of biological activity within adults by a factor of 10. This product does absolutely NOTHING from a nutritional and clinical point of view. Nothing at all. If the vendors were selling air capsules with nothing in the capsules, they would be providing just as much “nutrition” as they are with this product.

So what consumers get with products like this is very nice packaging, lots of pretty pictures with people smiling, a price that implies great value, but at the end of the day, zero clinical nutrition and their hard-earned money taken by hyper-marketers under the guise of “value”.

If one were to try to get the same amount DIM that you get from the Berkeley Formula from this formulation and hundreds of others like it, one would have to spend over $150 a month on this product and consume 6-12 bottles of this product per month depending on the capsule count of the bottle that the consumer may be taking. Sometimes this product, and others like it, come in bottles of 60 capsules and sometimes 120 capsules. The quantity of capsules in their bottle is irrelevant however and frankly a component of their hyper-marketing strategy. What is relevant from the perspective of nutritional science is that this product is entirely ineffective and has absolutely no biological or clinical relevance for consumers.

Do you now see how the Berkeley Formula is a very competitively priced product?

When you’re comparing nutritional products, you need to take a very close look at the quantity of nutrients that they provide, whether or not such quantity actually imparts beneficial biological activity within the body, whether or not the nutrient is formulated in a bioavailable manner and lastly whether or not the nutrient is co-delivered with other nutrients that enhance and add to its beneficial biological activity.

Unfortunately, discerning all of this requires advanced knowledge within the field of nutritional science, knowledge that average consumers do not have, and that is exactly why we see a plethora of supplement vendors online quoting our scientific papers at Berkeley to sell entirely ineffective DIM products to the public.

At this point having done the research that we have in this market, we can say with confidence that the vast majority of the DIM supplements that consumers come across on the Internet are entirely ineffective and they fall into one or more of the categories of case studies that we have discussed above. The DIM in such formulations is either not bioavailable or it’s not bioactive or if it is bioavailable with a meaningful quantity of DIM, the wrong excipients are being used for the delivery of the DIM that interfere with its biological activities or the wrong bioavailability technology is being employed with an inferior safety profile to what one finds in the Berkeley Formula.

This is why discerning consumers who consult with expert nutritional scientists prior to purchasing DIM supplements often turn to our product for a clinically efficacious DIM supplement.

This is also why a large number of the individuals who are members within our Monthly and Quarterly Program worldwide are doctors, nutritional scientists and biomedical investigators like ourselves.

Case Study #5

This product cites our work at Berkeley and makes all kinds of claims about how “scientists have shown that DIM promotes healthy estrogen metabolism” referring to our study that we did in Marin County, California, however, when you look at the label carefully, the label states that it has “900 mcg” of Diindolylmethane in it.

What the hyper-marketers in this case are doing is they are betting that the average American consumer does not know the difference between micrograms and milligrams and by listing a large number before the measurement type, they are betting that people will be more impressed by the number than what the number actually means.

Micrograms and milligrams are part of the metric measurement system that most Americans are not familiar with and this is how this company is exploiting people’s lack of knowledge.

Eash single milligram (mg) contains 1000 micrograms (mcg).

So a product containing 900 mcg of DIM in each capsule has less than 1 mg of DIM in it, because that amount equates to just 0.9 mg of DIM. 0.9 mg of DIM is not a biologically active quantity of DIM. This quantity of DIM achieves nothing. It has no nutritional value at all for anyone consuming it. Consumers would have to consume hundreds of these capsules in order to get the same quantity of DIM that they would get in just two of our capsules.

We hope that you have found these case studies to be informative and educational. 

Notes

1. Prospective Study of Fruit and Vegetable Intake and Risk of Prostate Cancer. Journal of the National Cancer Institute. 2007 Jul 24; Krish VA, Peters U, Mayne ST, Subar AF, Chatterjee N, Johnson CC, Hayes RB. Click here to view reference at the US National Library of Medicine.

2. Greater vegetable and fruit intake is associated with a lower risk of breast cancer among Chinese women. International Journal of Cancer. 2009 Jul 1;125(1):181-8. Zhang CX, Ho SC, Chen YM, Fu JH, Check SZ, Lin FY. Click here to view reference at the US National Library of Medicine.

3. Please visit our extensive references section at the end of our Science Page listing scientific articles on Diindolylmethane, Sulforaphane and Selenium.

Broccoli Bloom at the UC Berkeley Botanical Garden

Berkeley Botanical Garden
Berkeley Immune Support Formula Immune Booster Supplement
Alex Amini, M.D. Quote

Alex Amini, M.D.
Infectious Disease Specialist
Kaiser Permanente

Spinach
Spinach:
Lutein
Zeaxanthin
Citrus Fruits
Citrus Fruits:
Citrus Bioflavonoids
Tomato
Tomato:
Lycopene
Broccoli
Broccoli:
Diindolylmethane
Sulforaphane
Selenium
Spinach
Spinach:
Lutein
Zeaxanthin
  • Powerful Nutritional Immune Booster

    Bioavailable Nutrient Delivery System

  • Diindolylmethane (DIM):

    Immune, Breast, Prostate & Colon Heath

  • Sulforaphane:

    Cellular Detoxification

  • Selenium:

    Immune, Breast, Prostate & Vision Health

  • Lycopene:

    Cardiovascular, Breast & Prostate Health

  • Lutein:

    Immune, Vision, Prostate & Skin Health

  • Zeaxanthin:

    Vision Health

  • Vitamin D3:

    Immune Support & Bone Health

  • Citrus Bioflavonoids:

    Immune & Cardiovascular Health

  • Zinc:

    Immune, Breast, Prostate & Vision Health

Berkeley Immune Support Formula supplement facts sheet
Berkeley Immune Support Formula Capsule

Premium Immune Booster