SCIENCE

Multi-factorial Approach

The Berkeley Immune Support Formula is a unique dietary supplement that works in a multi-factorial way to boost the immune system. The ingredients within its unique and proprietary formula have been scientifically shown to enhance the immune system and support the health of multiple organ systems throughout the body: breast, prostate, cardiovascular, vision, skin and colon health.

Immune Modulation

The Berkeley Formula’s most important and differentiating attribute as a nutritional supplement is that, in a safe and natural way, it increases the sensitivity of cells in the body to the Interferon-Gamma protein (IFN-G) in addition to increasing the body’s Interferon-Gamma production. Interferon-Gamma is a key signaling protein within the immune system that boosts the ability of the body to defend itself.

In addition to Interferon-Gamma, the DIM complex in the Berkeley Formula also stimulates the production of the Granulocyte Colony Stimulating Factor (G-CSF) which is directly responsible for White Blood Cell production in the body, Interlukin-6 (IL-6), which is an important immune enhancing cytokine, and Interlukin-12 (IL-12) which stimulates the growth and function of T-Cells.

The scientists at UC Berkeley have additionally demonstrated that DIM synergizes with Interferon-Gamma in promoting the activity of the Major Histocompatibility Complex I (MHC-I)–an important molecular system that flags antigens to the immune system.

In addition to all of the above activities, DIM also downregulates excessive activity of NF-KB. NF-KB is a protein complex that controls inflammation in the body and over-activity of this protein complex is linked to excessive and undesirable inflammation. DIM is the first compound discovered in the field nutrition and medicine to have this very attractive dual mode of activity of simultaneously enhancing the immune system and down-regulating excessive inflammation stemming from excessive NF-KB activity. This unique dual activity is extremely significant from the perspective of clinical nutrition for conditions that require robust immune activation and the need to lower excessive inflammation at the same time.

A variety of factors affect the immune system. Sleep, regular exercise, nutrition, obesity, environmental toxins, age and lifestyle habits such as smoking are all important factors. Aging is particularly important as it affects all people regardless of their general lifestyle habits and it requires that individuals try to compensate for its effects by modifying the other factors influencing their immune system and general wellness.

While we hope that all who are reading this will make an effort to exercise regularly, get plenty of sleep, and maintain a healthy body weight, the Berkeley Formula is here to help with a nutritional immune booster that is so robust physicians and biomedical scientists from around the world have made it a regular part of their daily nutrition.

Other Ingredients in the Berkeley Immune Support Formula

Diindolylmethane is one of numerous important nutrients in the Berkeley Immune Support Formula. The following overview provides a brief description of the functionality and importance of the other ingredients in the Berkeley Formula:

Lycopene, the key phytonutrient found in tomatoes, is an antioxidant that promotes immune, cardiovascular, breast and prostate health. Selenium is another important antioxidant, endogenous to broccoli, that has been widely studied for its support of immune, breast, prostate, cardiovascular and vision health. Sulforaphane, discovered at the Johns Hopkins School of Medicine, activates phase II detoxification enzymes within the body that help to detoxify the body from harmful chemicals and carcinogens that build up through exposure to environmental pollution. Lutein and Zeaxanthin are two important phytonutrients found in spinach that promote vision health and support the immune system. Citrus Bioflavonoids derived from citrus fruits and citrus peel help to support the immune system and promote cardiovascular health. Vitamin D3 further bolsters the biological activities of the other ingredients and boosts the immune system in addition to promoting bone health. As DIM’s immune modulatory pathway is promoted by calcium-dependent protein kinase activity, the presence of Vitamin D3 helps to support DIM’s immune enhancing molecular biology

Molecular Structure of Diindolylmethane

Diindolylmethane (DIM)

The Immune System

The immune system is the body’s defense system. It consists of a complex network of cells, tissues, and organs and has a sensitive process of checks and balances that together generate an appropriate immune response that is prompt, accurate, effective and self-limiting. It has many different types of cells acting together as a team. Cytokines are the chemicals produced by these cells in order to communicate and orchestrate the attack. Binding to specific receptors on target cells, cytokines recruit many other cells and substances to the site of action to help direct the attack of the immune system.

Interferons are within the cytokine family of proteins. Interferons are especially important because they enhance the immune system’s ability to conduct surveillance within the body, enabling the system as a whole to function more effectively. There are three classes of Interferons: Alpha, Beta and Gamma. Interferon Alpha and Beta are produced by many cell types, including T-cells and B-cells. Interferon-Gamma is involved in the regulation of immune response.

Interferon-Gamma modulates nearly all phases of the immune response system, including the activation, growth and differentiation of T-cells, B-cells, macrophages, natural killer (NK) cells and other cell types such as endothelial cells and fibroblasts. Genetic defects in the IFN-G activation pathway are associated with susceptibility to severe micro-bacterial infections. IFN-G is hence regarded as a key immuno-regulator. It enhances the cytotoxic activity of T cells, macrophages and natural killer cells and as such it has antiproliferative effects.

Organs of the Immune System

Organs of the Immune System

Computer Image of Interferon-Gamma

Computer Image of Interferon-Gamma

Scientific References

Our references section consists of two parts. Part one consists of numerous scientific studies published by biomedical investigators at the US National Cancer Institute, United States Department of Agriculture, David and Alice Jurist Institute for Research, Ministry of Health of the Russian Federation, Georgetown Univeristy and UC Berkeley that discuss the molecular biology of Diindolylmethane in immune response enhancement at the cellular and systemic levels in addition to preclinical and human clinical studies on DIM’s immune modulatory biological activities. Part two consists of links to a comprehensive list of scientific references at the US National Library of Medicine regarding all of the ingredients in the Berkeley Immune Support Formula.

Important note for readers: while the scientific discoveries and clinical developments that we reference in this section or provide links to at the United States National Library of Medicine are extremely exciting, they are stepping stones in the studies of Diindolylmethane (DIM) and some of the other naturally occurring ingredients in the Berkeley Immune Support Formula. The exploration of clinical applications for Diindolylmethane is an emerging science. Only the US FDA has the authority to recognize a compound as a drug or therapeutic for a particular condition in the US and that only occurs after the compound has been thoroughly studied and its efficacy established in four consecutive human clinical trials. At this point in time, Diindolylmethane and the other naturally occurring ingredients in the Berkeley Immune Support Formula are regarded as dietary supplements and not therapeutics for any specific condition by the US FDA. The Berkeley Immune Support Formula is a nutritional supplement. Statements on this website have not been evaluated by the US Food and Drug Administration. The Berkeley Immune Support Formula is not intended to diagnose, treat, cure or prevent any disease.

Part I: Scientific References on DIM's Enhancement of the Immune Response System

Advances in Radiation Oncology 2021 6,100601. Li L, Chen R, Lin YT, Humayun A, Fornace AJ Jr, Li HH. Department of Oncology, Georgetown University Medical Center, Washington, DC; Georgetown College, Georgetown University, Washington, DC; and Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC.

International Journal of Molecular Sciences 2017 Jul 1;18(7). Liu M., Yasmeen R, Fukagawa NK, Yu L, Kim YS, Wang TTY. Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, MD 20892. Diet, Genomics and Immunology Lab, Beltsville Human Nutrition Research Center, Agricultural Research Service (ARS), United States Department of Agriculture (USDA), Beltsville, MD 20705, USA.

EPMA J. 2015 Dec 21;6:25. Ashrafian L, Sukhikh G, Kiselev V, Paltsev M, Drukh V, Kuznetsov I, Muyzhnek E, Apolikhina I, Andrianova E. Ministry of Health of the Russian Federation, Moscow, 86, Profsouznaya Str., Moscow, 117837 Russia.

In Vivo 2012 Mar-Apr;26(2):207-11. Sepkovic DW, Raucci L, Stein J, Carlisle AD, Auborn K, Ksieski HB, Nyirenda T, Bradlow HL. The David and Alice Jurist Institute for Research, Hackensack University Medical Center, Hackensack, NJ, 07601, USA.

Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2957-64. Sepkovic DW, Stein J, Carlisle AD, Ksieski HB, Auborn K, Bradlow HL. The David and Alice Jurist Institute for Research, Hackensack University Medical Center, Hackensack, New Jersey 07601, USA.

Journal of Nutritional Biochemistry 2008 May; 19(5): 336–344. Xue L, Pestka J, Maoxiang L, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California at Berkeley, 119 Morgan Hall, Berkeley, CA 94720-3104, USA.

Molecular Pharmacology 2006 Feb;69(2):430-9. Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California at Berkeley, 119 Morgan Hall, Berkeley, CA 94720-3104, USA.

Oncogene 2005 Mar 31;24(14):2343-53. Xue L, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California at Berkeley, 119 Morgan Hall, Berkeley, CA 94720-3104, USA.

Part II: Comprehensive Scientific References on DIM and other Ingredients in the Berkeley Immune Support Formula

Mustard Flowers and Seeds. Mustard Plant is within the Brassica Family.

Mustard Flowers and Seeds

SCIENCE

Multi-factorial Approach

The Berkeley Immune Support Formula is a unique dietary supplement that works in a multi-factorial way to boost the immune system. The ingredients within its unique and proprietary formula have been scientifically shown to enhance the immune system and support the health of multiple organ systems throughout the body: breast, prostate, cardiovascular, vision, skin and colon health.

Immune Modulation

The Berkeley Formula’s most important and differentiating attribute as a nutritional supplement is that, in a safe and natural way, it increases the sensitivity of cells in the body to the Interferon-Gamma protein (IFN-G) in addition to increasing the body’s Interferon-Gamma production. Interferon-Gamma is a key signaling protein within the immune system that boosts the ability of the body to defend itself.

In addition to Interferon-Gamma, the DIM complex in the Berkeley Formula also stimulates the production of the Granulocyte Colony Stimulating Factor (G-CSF) which is directly responsible for White Blood Cell production in the body, Interlukin-6 (IL-6), which is an important immune enhancing cytokine, and Interlukin-12 (IL-12) which stimulates the growth and function of T-Cells.

The scientists at UC Berkeley have additionally demonstrated that DIM synergizes with Interferon-Gamma in promoting the activity of the Major Histocompatibility Complex I (MHC-I)–an important molecular system that flags antigens to the immune system.

In addition to all of the above activities, DIM also downregulates excessive activity of NF-KB. NF-KB is a protein complex that controls inflammation in the body and over-activity of this protein complex is linked to excessive and undesirable inflammation. DIM is the first compound discovered in the field nutrition and medicine to have this very attractive dual mode of activity of simultaneously enhancing the immune system and down-regulating excessive inflammation stemming from excessive NF-KB activity. This unique dual activity is extremely significant from the perspective of clinical nutrition for conditions that require robust immune activation and the need to lower excessive inflammation at the same time.

A variety of factors affect the immune system. Sleep, regular exercise, nutrition, obesity, environmental toxins, age and lifestyle habits such as smoking are all important factors. Aging is particularly important as it affects all people regardless of their general lifestyle habits and it requires that individuals try to compensate for its effects by modifying the other factors influencing their immune system and general wellness.

While we hope that all who are reading this will make an effort to exercise regularly, get plenty of sleep, and maintain a healthy body weight, the Berkeley Formula is here to help with a nutritional immune booster that is so robust physicians and biomedical scientists from around the world have made it a regular part of their daily nutrition.

Other Ingredients in the Berkeley Immune Support Formula

Diindolylmethane is one of numerous important nutrients in the Berkeley Immune Support Formula. The following overview provides a brief description of the functionality and importance of the other ingredients in the Berkeley Formula:

Lycopene, the key phytonutrient found in tomatoes, is an antioxidant that promotes immune, cardiovascular, breast and prostate health. Selenium is another important antioxidant, endogenous to broccoli, that has been widely studied for its support of immune, breast, prostate, cardiovascular and vision health. Sulforaphane, discovered at the Johns Hopkins School of Medicine, activates phase II detoxification enzymes within the body that help to detoxify the body from harmful chemicals and carcinogens that build up through exposure to environmental pollution. Lutein and Zeaxanthin are two important phytonutrients found in spinach that promote vision health and support the immune system. Citrus Bioflavonoids derived from citrus fruits and citrus peel help to support the immune system and promote cardiovascular health. Vitamin D3 further bolsters the biological activities of the other ingredients and boosts the immune system in addition to promoting bone health. As DIM’s immune modulatory pathway is promoted by calcium-dependent protein kinase activity, the presence of Vitamin D3 helps to support DIM’s immune enhancing molecular biology.

Molecular Structure of Diindolylmethane

Diindolylmethane (DIM)

The Immune System

The immune system is the body’s defense system. It consists of a complex network of cells, tissues, and organs and has a sensitive process of checks and balances that together generate an appropriate immune response that is prompt, accurate, effective and self-limiting. It has many different types of cells acting together as a team. Cytokines are the chemicals produced by these cells in order to communicate and orchestrate the attack. Binding to specific receptors on target cells, cytokines recruit many other cells and substances to the site of action to help direct the attack of the immune system.

Interferons are within the cytokine family of proteins. Interferons are especially important because they enhance the immune system’s ability to conduct surveillance within the body, enabling the system as a whole to function more effectively. There are three classes of Interferons: Alpha, Beta and Gamma. Interferon Alpha and Beta are produced by many cell types, including T-cells and B-cells. Interferon-Gamma is involved in the regulation of immune response.

Interferon-Gamma modulates nearly all phases of the immune response system, including the activation, growth and differentiation of T-cells, B-cells, macrophages, natural killer (NK) cells and other cell types such as endothelial cells and fibroblasts. Genetic defects in the IFN-G activation pathway are associated with susceptibility to severe micro-bacterial infections. IFN-G is hence regarded as a key immuno-regulator. It enhances the cytotoxic activity of T cells, macrophages and natural killer cells and as such it has antiproliferative effects.

Organs of the Immune System

Organs of the Immune System

Computer Image of Interferon-Gamma

Computer Image of Interferon-Gamma

Scientific References

Our references section consists of two parts. Part one consists of numerous scientific studies published by biomedical investigators at the US National Cancer Institute, United States Department of Agriculture, David and Alice Jurist Institute for Research, Ministry of Health of the Russian Federation, Georgetown Univeristy and UC Berkeley that discuss the molecular biology of Diindolylmethane in immune response enhancement at the cellular and systemic levels in addition to preclinical and human clinical studies on DIM’s immune modulatory biological activities. Part two consists of links to a comprehensive list of scientific references at the US National Library of Medicine regarding all of the ingredients in the Berkeley Immune Support Formula.

Important note for readers: while the scientific discoveries and clinical developments that we reference in this section or provide links to at the United States National Library of Medicine are extremely exciting, they are stepping stones in the studies of Diindolylmethane (DIM) and some of the other naturally occurring ingredients in the Berkeley Immune Support Formula. The exploration of clinical applications for Diindolylmethane is an emerging science. Only the US FDA has the authority to recognize a compound as a drug or therapeutic for a particular condition in the US and that only occurs after the compound has been thoroughly studied and its efficacy established in four consecutive human clinical trials. At this point in time, Diindolylmethane and the other naturally occurring ingredients in the Berkeley Immune Support Formula are regarded as dietary supplements and not therapeutics for any specific condition by the US FDA. The Berkeley Immune Support Formula is a nutritional supplement. Statements on this website have not been evaluated by the US Food and Drug Administration. The Berkeley Immune Support Formula is not intended to diagnose, treat, cure or prevent any disease.

Part I: Scientific References on DIM's Enhancement of the Immune Response System

Advances in Radiation Oncology 2021 6,100601. Li L, Chen R, Lin YT, Humayun A, Fornace AJ Jr, Li HH. Department of Oncology, Georgetown University Medical Center, Washington, DC; Georgetown College, Georgetown University, Washington, DC; and Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC.

International Journal of Molecular Sciences 2017 Jul 1;18(7). Liu M., Yasmeen R, Fukagawa NK, Yu L, Kim YS, Wang TTY. Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, MD 20892. Diet, Genomics and Immunology Lab, Beltsville Human Nutrition Research Center, Agricultural Research Service (ARS), United States Department of Agriculture (USDA), Beltsville, MD 20705, USA.

EPMA J. 2015 Dec 21;6:25. Ashrafian L, Sukhikh G, Kiselev V, Paltsev M, Drukh V, Kuznetsov I, Muyzhnek E, Apolikhina I, Andrianova E. Ministry of Health of the Russian Federation, Moscow, 86, Profsouznaya Str., Moscow, 117837 Russia.

In Vivo 2012 Mar-Apr;26(2):207-11. Sepkovic DW, Raucci L, Stein J, Carlisle AD, Auborn K, Ksieski HB, Nyirenda T, Bradlow HL. The David and Alice Jurist Institute for Research, Hackensack University Medical Center, Hackensack, NJ, 07601, USA.

Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2957-64. Sepkovic DW, Stein J, Carlisle AD, Ksieski HB, Auborn K, Bradlow HL. The David and Alice Jurist Institute for Research, Hackensack University Medical Center, Hackensack, New Jersey 07601, USA.

Journal of Nutritional Biochemistry 2008 May; 19(5): 336–344. Xue L, Pestka J, Maoxiang L, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California at Berkeley, 119 Morgan Hall, Berkeley, CA 94720-3104, USA.

Molecular Pharmacology 2006 Feb;69(2):430-9. Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California at Berkeley, 119 Morgan Hall, Berkeley, CA 94720-3104, USA.

Oncogene 2005 Mar 31;24(14):2343-53. Xue L, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California at Berkeley, 119 Morgan Hall, Berkeley, CA 94720-3104, USA.

Part II: Comprehensive Scientific References on DIM and other Ingredients in the Berkeley Immune Support Formula

Mustard Flowers and Seeds. Mustard Plant is within the Brassica Family.

Mustard Flowers and Seeds
Berkeley Immune Support Formula Immune Booster Supplement
Alex Amini, M.D. Quote

Alex Amini, M.D.
Infectious Disease Specialist
Kaiser Permanente

Tomato
Tomato:
Lycopene
Broccoli
Broccoli:
Diindolylmethane
Sulforaphane
Selenium
Spinach
Spinach:
Lutein
Zeaxanthin
Citrus Fruits
Citrus Fruits:
Citrus Bioflavonoids
Tomato
Tomato:
Lycopene
  • Powerful Nutritional Immune Booster

    Bioavailable Nutrient Delivery System

  • Diindolylmethane (DIM):

    Immune, Breast, Prostate & Colon Heath

  • Sulforaphane:

    Cellular Detoxification

  • Selenium:

    Immune, Breast, Prostate & Vision Health

  • Lycopene:

    Cardiovascular, Breast & Prostate Health

  • Lutein:

    Immune, Vision, Prostate & Skin Health

  • Zeaxanthin:

    Vision Health

  • Vitamin D3:

    Immune Support & Bone Health

  • Citrus Bioflavonoids:

    Immune & Cardiovascular Health

  • Zinc:

    Immune, Breast, Prostate & Vision Health

Berkeley Immune Support Formula supplement facts sheet
Berkeley Immune Support Formula Capsule

Premium Immune Booster