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What is a Bone Marrow Stromal Cell and How Does it Contribute to the Immune System?

Bone marrow stromal cells (BMSCs), also known as mesenchymal stem cells (MSCs), are multipotent stromal cells that play a crucial role in the bone marrow microenvironment. They are known for their ability to differentiate into a variety of cell types and their significant contribution to the regulation and support of the immune system. This review explores the nature, functions, and the vital role of BMSCs in immune regulation and homeostasis.

BMSCs are a heterogeneous population of cells found in the bone marrow’s stromal compartment. They are capable of differentiating into osteoblasts, chondrocytes, adipocytes, and other cell types under specific physiological conditions. These cells are characterized by their expression of surface markers such as CD73, CD90, and CD105 while lacking hematopoietic markers like CD34 and CD45 (Pittenger et al., “Science”, 1999).

In the bone marrow, BMSCs provide structural and functional support to hematopoietic stem cells (HSCs) and contribute to the formation of the hematopoietic microenvironment. They produce extracellular matrix components and secrete a range of cytokines and growth factors, which are crucial for HSC maintenance and differentiation (Méndez-Ferrer et al., “Nature”, 2010).

BMSCs have been widely recognized for their immunomodulatory capabilities. They can interact with various immune cells, including T cells, B cells, dendritic cells, and natural killer cells, influencing their function and activity. This interaction often results in the suppression of immune responses, particularly under conditions of inflammation or autoimmune disorders (Uccelli et al., “Nature Reviews Immunology”, 2008).

One of the critical functions of BMSCs in immune regulation is their effect on T cell proliferation and activation. BMSCs can inhibit T cell proliferation, which is triggered by antigen presentation, by inducing cell cycle arrest in the G0/G1 phase. This effect is mediated through the secretion of soluble factors like prostaglandin E2 (PGE2), indoleamine 2,3-dioxygenase (IDO), and transforming growth factor-beta (TGF-β) (Di Nicola et al., “Blood”, 2002).

 

BMSCs contribute to the generation and function of various immune cells through their support in hematopoiesis. They provide a niche for HSCs and directly influence their differentiation into diverse blood cell lineages, including immune cells (Morrison and Scadden, “Cell”, 2014).

The immunomodulatory properties of BMSCs have sparked interest in their therapeutic potential, particularly in treating immune-related disorders, such as graft-versus-host disease (GvHD) and autoimmune diseases. Clinical studies have shown promising results in using BMSCs to modulate immune responses in these conditions (Le Blanc et al., “The Lancet”, 2008).

Bone marrow stromal cells are pivotal in shaping the immune system’s functionality and response. Their ability to modulate immune reactions, support hematopoiesis, and interact with various immune cells underscores their significance in maintaining immune homeostasis. Understanding the multifaceted roles of BMSCs provides valuable insights into immune regulation and opens avenues for novel therapeutic strategies in treating immune-mediated disorders.

 

References:

Pittenger M.F., et al. “Multilineage Potential of Adult Human Mesenchymal Stem Cells”. Science, 1999.

Méndez-Ferrer S., et al. “Mesenchymal and haematopoietic stem cells form a unique bone marrow niche”. Nature, 2010.

Uccelli A., et al. “Mesenchymal stem cells in health and disease”. Nature Reviews Immunology, 2008.

Di Nicola M., et al. “Human Bone Marrow Stromal Cells Suppress T-lymphocyte Proliferation Induced by Cellular or Nonspecific Mitogenic Stimuli”. Blood, 2002.

Morrison S.J., Scadden D.T. “The bone marrow niche for haematopoietic stem cells”. Cell, 2014.

Le Blanc K., et al. “Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells”. The Lancet, 2008.

If you have any questions about the Berkeley Formula Diindolylmethane (DIM) Supplement & Immune System Booster, please feel free to contact our customer service department at 877-777-0719 (9AM-5PM M-F PST) and our representatives will be happy to answer any questions that you may have. We will be glad to share with you why the Berkeley Formula is the DIM supplement of choice by nutritional scientists, medical professionals and biomedical investigators worldwide.

Romanesco Broccoli with a Natural Fractal Pattern

Romanesco Broccoli

What is a Bone Marrow Stromal Cell and How Does it Contribute to the Immune System?

Bone marrow stromal cells (BMSCs), also known as mesenchymal stem cells (MSCs), are multipotent stromal cells that play a crucial role in the bone marrow microenvironment. They are known for their ability to differentiate into a variety of cell types and their significant contribution to the regulation and support of the immune system. This review explores the nature, functions, and the vital role of BMSCs in immune regulation and homeostasis.

BMSCs are a heterogeneous population of cells found in the bone marrow’s stromal compartment. They are capable of differentiating into osteoblasts, chondrocytes, adipocytes, and other cell types under specific physiological conditions. These cells are characterized by their expression of surface markers such as CD73, CD90, and CD105 while lacking hematopoietic markers like CD34 and CD45 (Pittenger et al., “Science”, 1999).

In the bone marrow, BMSCs provide structural and functional support to hematopoietic stem cells (HSCs) and contribute to the formation of the hematopoietic microenvironment. They produce extracellular matrix components and secrete a range of cytokines and growth factors, which are crucial for HSC maintenance and differentiation (Méndez-Ferrer et al., “Nature”, 2010).

BMSCs have been widely recognized for their immunomodulatory capabilities. They can interact with various immune cells, including T cells, B cells, dendritic cells, and natural killer cells, influencing their function and activity. This interaction often results in the suppression of immune responses, particularly under conditions of inflammation or autoimmune disorders (Uccelli et al., “Nature Reviews Immunology”, 2008).

One of the critical functions of BMSCs in immune regulation is their effect on T cell proliferation and activation. BMSCs can inhibit T cell proliferation, which is triggered by antigen presentation, by inducing cell cycle arrest in the G0/G1 phase. This effect is mediated through the secretion of soluble factors like prostaglandin E2 (PGE2), indoleamine 2,3-dioxygenase (IDO), and transforming growth factor-beta (TGF-β) (Di Nicola et al., “Blood”, 2002).

 

BMSCs contribute to the generation and function of various immune cells through their support in hematopoiesis. They provide a niche for HSCs and directly influence their differentiation into diverse blood cell lineages, including immune cells (Morrison and Scadden, “Cell”, 2014).

The immunomodulatory properties of BMSCs have sparked interest in their therapeutic potential, particularly in treating immune-related disorders, such as graft-versus-host disease (GvHD) and autoimmune diseases. Clinical studies have shown promising results in using BMSCs to modulate immune responses in these conditions (Le Blanc et al., “The Lancet”, 2008).

Bone marrow stromal cells are pivotal in shaping the immune system’s functionality and response. Their ability to modulate immune reactions, support hematopoiesis, and interact with various immune cells underscores their significance in maintaining immune homeostasis. Understanding the multifaceted roles of BMSCs provides valuable insights into immune regulation and opens avenues for novel therapeutic strategies in treating immune-mediated disorders.

 

References:

Pittenger M.F., et al. “Multilineage Potential of Adult Human Mesenchymal Stem Cells”. Science, 1999.

Méndez-Ferrer S., et al. “Mesenchymal and haematopoietic stem cells form a unique bone marrow niche”. Nature, 2010.

Uccelli A., et al. “Mesenchymal stem cells in health and disease”. Nature Reviews Immunology, 2008.

Di Nicola M., et al. “Human Bone Marrow Stromal Cells Suppress T-lymphocyte Proliferation Induced by Cellular or Nonspecific Mitogenic Stimuli”. Blood, 2002.

Morrison S.J., Scadden D.T. “The bone marrow niche for haematopoietic stem cells”. Cell, 2014.

Le Blanc K., et al. “Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells”. The Lancet, 2008.

If you have any questions about the Berkeley Formula Diindolylmethane (DIM) Supplement & Immune System Booster, please feel free to contact our customer service department at 877-777-0719 (9AM-5PM M-F PST) and our representatives will be happy to answer any questions that you may have. We will be glad to share with you why the Berkeley Formula is the DIM supplement of choice by nutritional scientists, medical professionals and biomedical investigators worldwide.

Romanesco Broccoli with a Natural Fractal Pattern

Romanesco Broccoli
Berkeley Immune Support Formula Immune Booster Supplement
Alex Amini, M.D. Quote

Alex Amini, M.D.
Infectious Disease Specialist
Kaiser Permanente

Broccoli
Broccoli:
Diindolylmethane
Sulforaphane
Selenium
Spinach
Spinach:
Lutein
Zeaxanthin
Citrus Fruits
Citrus Fruits:
Citrus Bioflavonoids
Tomato
Tomato:
Lycopene
Broccoli
Broccoli:
Diindolylmethane
Sulforaphane
Selenium
  • Powerful Nutritional Immune Booster

    Bioavailable Nutrient Delivery System

  • Diindolylmethane (DIM):

    Immune, Breast, Prostate & Colon Heath

  • Sulforaphane:

    Cellular Detoxification

  • Selenium:

    Immune, Breast, Prostate & Vision Health

  • Lycopene:

    Cardiovascular, Breast & Prostate Health

  • Lutein:

    Immune, Vision, Prostate & Skin Health

  • Zeaxanthin:

    Vision Health

  • Vitamin D3:

    Immune Support & Bone Health

  • Citrus Bioflavonoids:

    Immune & Cardiovascular Health

  • Zinc:

    Immune, Breast, Prostate & Vision Health

Berkeley Immune Support Formula supplement facts sheet
Berkeley Immune Support Formula Capsule

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