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  • Powerful Natural Immune Booster
    Bioavailable Nutrient Delivery System

  • Diindolylmethane (DIM)
    Immune, Breast, Prostate, Colon & Skin Health

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    Cellular Detoxification

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  • Vitamins C, D3 and E
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Diindolylmethane DIM Natural Immune System Booster

 

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HEALTHCARE PROFESSIONALS

 

The information in this section is solely intended for healthcare professionals and biomedical investigators.

 

The Berkeley Immune Support Formula is available on a wholesale basis to certified healthcare professionals. Interested professionals should scan their credentials / business license into a PDF file and e-mail it to us for consideration. Upon approval, you will receive wholesale account information from our customer service department. Please send your information to the following e-mail address for consideration:

 

Important note for readers: while many of the scientific discoveries and clinical developments listed in this section are extremely exciting, they are stepping stones in the studies of Diindolylmethane (DIM) and some of the other key natural ingredients in Berkeley Immune Support Formula. The exploration of clinical applications for Diindolylmethane is an emerging science. Only the US FDA has the authority to recognize a compound as a drug or therapeutic for a particular condition in the US and that only occurs after the compound has been thoroughly studied and its efficacy established in four consecutive human clinical trials. At this point in time, Diindolylmethane and the other natural ingredients in the Berkeley Immune Support Formula are regarded as dietary supplements and not therapeutics for any specific condition by the US FDA. The Berkeley Immune Support Formula is a nutritional supplement. Statements on this website have not been evaluated by the US Food and Drug Administration. The Berkeley Immune Support Formula is not intended to diagnose, treat, cure or prevent any disease.

 

SCIENTIFIC BRIEFING FOR HEALTHCARE PROFESSIONALS AND BIOMEDICAL INVESTIGATORS

 

Diindolylmethane (DIM) Immune Modulating Properties

 

Induction of Interferon-Gamma Receptors on Cell Surfaces

 

Stimulation of Interferon-Gamma, G-CSF, IL-12 & IL-6 Production

 

Synergy with Interferon-Gamma in Expression of the MHC-I Complex

 

Selection of Data from the Reference Section

 

DIM In-Vivo Affect on Key Immune

Modulating Cytokines

 

Modulation of Cytokines by Diindolylmethane DIM

In this study DIM was administered orally at 30mg/kg of body weight.

 


 

DIM In-Vivo Anti-Viral Activity

Through Immune Modulation

 

Antiviral Activity of Diindolylmethane DIM

 

(Reference: Xue L, Pestka J, Maoxiang L, Firestone GL, Bjeldanes LF, 3,3′-Diindolylmethane stimulates murine immune function in vitro and in vivo, Journal of Nutritional Biochemistry,

published online, 8-20-07.)

 


 

DIM Stimulates Transcript Expression of Interferon-γ

and Related Genes in Human Breast Cancer Cells

 

Diindolylmethane DIM Stimulates Transcription of Interferon Gamma Genes

 


 

Activation and Potentiation of Interferon-γ by DIM:

Stimulation of Interferon-γ Receptor 1 Production

 

Diindolylmethane DIM increases Interferon Gamma Receptor Production

 


 

Potentiation of Interferon-γ Mediated Cell Cycle Arrest by DIM in Human Breast Cancer Cells

Diindolylmethane DIM Synergizes with Interferon Gamma in Anticancer Activity

 


 

DIM Enhances Interferon-γ Induced Expression of MHC-I Complex in Human Breast Cancer Cells

 

(Please Note Section D of this figure. DIM may be used as an adjuvant to IFNγ treatment models because of this unique synergistic effect on the MHC-I Complex. This synergy is currently under investigation for HIV, HPV, Hepatitis and multiple forms of cancer.)

 

Diindolylmethane DIM synergizes with Interferon Gamma

 

Diindolylmethane DIM Synergizes with Interferon Gamma

 

Diindolylmethane DIM synergizes with Interferon Gamma

 

 

Diindolylmethane DIM synergizes with Interferon Gamma

Fig 8. The expression level of MHC-I complex on the MCF-7 cell surface. A, cells were treated with different concentrations of IFN-Gamma for 16 h. B and C, cells were pretreated with DMSO (control) or 30 M DIM for 48 h, followed by 0.1 ng/ml of IFN-Gamma (B) or 10 ng/ml of IFN-Gamma (C) for another 16 h. One million cells were incubated in 90 l of PBS with 10 l of FITC-conjugated anti-HLA-ABC mouse monoclonal antibody. The fluorescence intensity was measured by flow cytometry using a Coulter Elite instrument and analyzed by WinMDI 2.8 software provided by Duke University. D, the expression of HLA class I complex was calculated as %PC (open bars) and MFV (cross-hatched bars).

(Reference: Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, Bjeldanes LF, Activation and Potentiation of Interferon-(gamma) Signaling by 3,3'-Diindolylmethane in MCF-7 Breast Cancer Cells, Molecular Pharmacology, Nov. 2, 2005)


 

DIM and Taxol Synergize to Promote Apoptosis

 

Diindolylmethane DIM synergizes with Taxol to Promote Apoptosis

 

Diindolylmethane DIM Synergizes with Taxol

 

Diindolylmethane DIM synergizes with Taxol

 

Diindolylmethane DIM synergizes with Taxol

(Reference: K. McGuire, N. Ngoubilly, M. Neavyn, S. Lanza-Jacoby. 3,3′-Diindolylmethane and Paclitaxel Act Synergistically to Promote Apoptosis in HER2/Neu Human Breast Cancer Cells. Journal of Surgical Research, 2006 May 15;132(2):208-13. Department of Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107)

 


 

In-Vivo Animal Study: DIM Inhibits DMBA-induced

Mammary Tumor Growth

Diindolylmethane DIM Anticancer Activity

(Reference: Chen I, McDougal A, Wang F, Safe S, Carcinogenesis, vol. 19, no.9. pp.1631. 1998.)

 


 

In-Vivo Animal Study: DIM Inhibits Growth of Human Mammary Tumor Cells in Athymic Mice

 

Diindolylmethane DIM Anticancer Activity

(Reference: Chang X., Tou J.C., Hong C., Kim H.A., Riby J.E., Firestone G.L., Bjeldanes L.F., 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice, Carcinogenesis, Janurary 2005, pp.771-778.)

 

Additional References on Diindolylmethane (DIM)

 

General information about DIM is available at the

Diindolylmethane Information Resource Center

 

Detailed information regarding DIM's immune activation properties is available at the

Diindolylmethane Immune Activation Data Center

 

  • Powerful Natural Immune Booster
    Bioavailable Nutrient Delivery System

  • Diindolylmethane (DIM)
    Immune, Breast, Prostate, Colon & Skin Health

  • Sulforaphane
    Cellular Detoxification

  • Selenium
    Immune, Breast, Prostate & Vision Health

  • Lycopene
    Cardiovascular, Breast & Prostate Health

  • Lutein
    Immune, Vision & Prostate Health

  • Zeaxanthin
    Vision Health

  • Vitamins C, D3 and E
    Immune Support & Bone Health

  • Citrus Bioflavonoids
    Immune & Cardiovascular Health

 

 

 

 

 

Note to Consumers

 

The Berkeley Immune Support Formula is a nutritional supplement. Statements on this website have not been evaluated by the US Food and Drug administration. The product featured is not intended to diagnose, treat, cure or prevent any disease. For medical advice please contact a licensed healthcare professional.

 

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