Diindolylmethane (DIM) Immune Activation Data & Reference Center

Diindolylmethane (DIM) Immune Activation Data CenterscientistDiindolylmethane (DIM) Immune Activation Data Center

 

The goal of the Diindolylmethane Immune Activation Data & Reference Center is to provide an overview of relevant scientific data & references on Diindolylmethane's immune activating properties for healthcare professionals and biomedical investigators interested in collaborating with Berkeley BioSciences, Inc. in scientific studies or human clinical trials of Diindolylmethane (DIM) in the future. The content of this data & reference center is intended solely for health professionals and biomedical investigators.

Diindolylmethane (DIM) is a naturally occurring compound within Brassica vegetables (broccoli, cauliflower, cabbage, kale, Brussels sprouts). Healthcare professionals can request PDF copies of the scientific papers published at UC Berkeley cited in this data center. As new scientific papers are published regarding DIM's immune modulatory properties, we will add information from those papers to this data center which is intended for educational use by medical professionals and biomedical investigators only.

Important note for readers: while the scientific discoveries and clinical developments that we reference in this data & reference center intended for medical professionals are extremely exciting, they are stepping stones in the studies of Diindolylmethane (DIM). The exploration of clinical applications for Diindolylmethane is an emerging science. Only the US FDA has the authority to recognize a compound as a drug or therapeutic for a particular condition in the US and that only occurs after the compound has been thoroughly studied and its efficacy established in four consecutive human clinical trials. At this point in time, Diindolylmethane and the other naturally occurring ingredients in the Berkeley Immune Support Formula are regarded as dietary supplements and not therapeutics for any specific condition by the US FDA. The Berkeley Immune Support Formula is a nutritional supplement. Statements on this website have not been evaluated by the US Food and Drug Administration. The Berkeley Immune Support Formula is not intended to diagnose, treat, cure or prevent any disease.

 

Diindolylmethane (DIM) Immune Modulating Properties Include:

 

Stimulation of Interferon-γ Sensitivity by Increasing IFN-γ Receptors

 

Stimulation of Interferon-γ, G-CSF, IL-6 and IL-12 Production

 

Synergy with Interferon-γ in Expression of the MHC-I Complex

Scientific References:

Dose-Dependent Responses of I3C and DIM on T-Cell Activation in the Human T Lymphocyte Jurkat Cell Line. Int J Mol Sci. 2017 Jul 1;18(7). pii: E1409. doi: 10.3390/ijms18071409.Liu M, Yasmeen R, Fukagawa NK, Yu L, Kim YS, Wang TTY. Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Diet, Genomics and Immunology Lab, Beltsville Human Nutrition Research Center,Agricultural Research Service (ARS), United States Department of Agriculture(USDA), Beltsville, MD 20705, USA. Click here to view reference at the US National Libraryof Medicine.

 

Double-blind randomized placebo-controlled multicenter clinical trial (phase IIa) on diindolylmethane's efficacy and safety in the treatment of CIN: implications for cervical cancer prevention. EPMA J. 2015 Dec 21;6:25. doi: 10.1186/s13167-015-0048-9. eCollection 2015. Ashrafian L, Sukhikh G, Kiselev V, Paltsev M, Drukh V, Kuznetsov I, Muyzhnek E, Apolikhina I, Andrianova E. Ministry of Health of the Russian Federation, Moscow, 86, Profsouznaya Str., Moscow, 117837 Russia. Click here to view reference at the US National Libraryof Medicine.

 

3,3'-Diindolylmethane increases serum interferon-γ levels in the K14-HPV16 transgenic mouse model for cervical cancer. In Vivo. 2012 Mar-Apr;26(2):207-11. Sepkovic DW(1), Raucci L, Stein J, Carlisle AD, Auborn K, Ksieski HB, Nyirenda T, Bradlow HL.The David and Alice Jurist Institute for Research, Hackensack University Medical Center, Hackensack, NJ, USA. Click here to view reference at the US National Libraryof Medicine.

 

Diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism, and enhances immune response in the K14-HPV16 transgenic mouse model. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2957-64. doi: 10.1158/1055-9965.EPI-09-0698. Epub 2009 Oct 27. Sepkovic DW(1), Stein J, Carlisle AD, Ksieski HB, Auborn K, Bradlow HL. The David and Alice Jurist Institute for Research, Hackensack University Medical Center, Hackensack, New Jersey 07601, USA. Click here to view reference at the US National Libraryof Medicine.

3,3′-Diindolylmethane stimulates murine immune function in vitro and in vivo,  Xue L, Pestka J, Maoxiang L, Firestone GL, Bjeldanes LF,  Journal of Nutritional Biochemistry, published online, 8-20-07. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 94720-3104, USA. Click here to view reference at the US National Libraryof Medicine.

Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells. Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 94720-3104, USA. Molecular Pharmacology. 2006 Feb;69(2):430-9. Click here to view reference at the US National Libraryof Medicine.
 

DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways. Xue L, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California, 119 Morgan Hall, Berkeley, CA 94720-3104, USA. Oncogene. 2005 Mar 31;24(14):2343-53. Click here to view reference at the US National Libraryof Medicine.

 

Data Briefing from Refrences Provided Above:

 

DIM In-Vivo Affect on Key Immune Modulating Cytokines

Diindolylmethane (DIM) Immune Activation Data Center

(In this study DIM was administered orally at 30mg/kg of body weight.)

 


 

Detailed Data Overview from the Referenced Papers:

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

 

Diindolylmethane (DIM) Immune Activation Data Center

 

 

 

Diindolylmethane (DIM) Immune Activation Data Center

 

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

 

Diindolylmethane (DIM) Immune Activation Data Center

Because of these immune enhancing properties, DIM is currently sold as an immune enhancing dietary supplement: www.BerkeleyFormula.com.

Note: The Berkeley Immune Support Formula is a nutritional supplement. Statements on this website have not been evaluated by the US Food and Drug Administration. The Berkeley Immune Support Formula is not intended to diagnose, treat, cure or prevent any disease.

2007-2019 Diindolylmethane Immune Activation Data & Reference Center